Bacteria exploit platelets.
نویسنده
چکیده
In this issue of Blood, Arman et al show that bacteria use immunoglobulin G (IgG) from plasma to engage platelet surface receptors FcγRIIA and integrin αIIbβ3 to induce platelet activation, which is further facilitated by platelet factor 4 (PF4).
منابع مشابه
Well as Generation of Txa 2 . These Secreted
agonists provide a boost to the already-initiated platelet inside-out signaling, causing robust platelet aggregation. The PF4 secreted from the a-granules in turn binds more bacteria and the vicious cycle continues (see figure). Recent discoveries indicate that platelets express Toll-like and purinergic receptors which help in detection of bacterial infection and release of a range of bacterici...
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عنوان ژورنال:
- Blood
دوره 123 20 شماره
صفحات -
تاریخ انتشار 2014